Mechanism of Baicalein in the treatment of arthritis by regulating JNK/ERK/p38MAPK and PI3K/Akt signaling pathways

The present study aimed to investigate the anti-inflammatory effects of Baicalein on human osteoarthritic chondrocytes and its molecular mechanisms, explore related events that may occur. extracted were stimulated with interleukins. After administered different concentrations Baicalein, survival rate was observed. Apoptosis detected by apoptosis assay kit. effect NO production using Griess reagent expressions IL-6 PGE2 ELISA. apoptotic proteins PI3/Akt, NF-kB MAPK cascade WB assay. significantly increased decreased NO, PGE2. COX-2 induced iNOS reduced in a dose-dependent manner under administration Baicalein. In addition, NF-κB signaling pathway, inhibited activation JNK, ERK p38 cascades. Inflammatory mediators play key role pathogenesis osteoarthritis. Baicalin inhibits expression inflammatory osteoarthritis regulates JNK/ERK/p38 PBK/Akt experiment evaluated anti-osteomyelitis order discover new treatment strategies.